Antisense Oligonucleotides (ASOs) can be used to block or stimulate mRNA resulting in blocking or promoting the target protein[1].

What is the difference between ASO and siRNA? ASOs have one strand while siRNAs have two. Can help cure various genetic diseases. Key challenge is drug delivery[2].

ASO drugs end with '-rsen'. Antiviral ASOs end with -'virsen'[1].

Can be used to treat an individual patient with a unique disease thus raising regulatory/ethical concerns[3].

Milasen became the first drug approved for a single person named Mila[4].

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